Alternative splicing increases the diversity of th...[DNA. 1987]

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1: DNA. 1987 Oct;6(5):389-94.Links

Alternative splicing increases the diversity of the human protein kinase C family.

Coussens L, Rhee L, Parker PJ, Ullrich A.

Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.

Isolation of two protein kinase C (PKC) cDNA clones containing divergent carboxy-terminal sequences suggested a common genetic origin for these cDNAs. Partial characterization of the hPKC beta chromosomal gene provided direct evidence for the existence of two adjacent carboxy-terminal exons (beta 1 and beta 2) that are alternatively spliced to generate two types of hPKC beta sequences. PKC beta 1 and beta 2 mRNAs are expressed in a selective manner in both human hematopoietic cells and bovine brain tissues.

PMID: 3677994 [PubMed - indexed for MEDLINE]

Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs.
Nucleic Acids Res. 1994 Feb 25; 22(4):646-55.

[Nucleic Acids Res. 1994]
Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.
J Biol Chem. 1993 Mar 5; 268(7):4997-5004.

[J Biol Chem. 1993]
Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing.
J Biol Chem. 1993 May 15; 268(14):10627-35.

[J Biol Chem. 1993]
ReviewThe molecular heterogeneity of protein kinase C and its implications for cellular regulation.
Nature. 1988 Aug 25; 334(6184):661-5.

[Nature. 1988]
ReviewProtein kinase C.
J Cell Physiol Suppl. 1987; Suppl 5:53-6.

[J Cell Physiol Suppl. 1987]
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Cited by 7 PubMed Central articles

ReviewProtein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis.
Webb BL, Hirst SJ, Giembycz MA. Br J Pharmacol. 2000 Aug; 130(7):1433-52.

[Br J Pharmacol. 2000]
ReviewThe extended protein kinase C superfamily.
Mellor H, Parker PJ. Biochem J. 1998 Jun 1; 332 ( Pt 2):281-92.

[Biochem J. 1998]
ReviewProtein kinase C isoenzymes: divergence in signal transduction?
Hug H, Sarre TF. Biochem J. 1993 Apr 15; 291 ( Pt 2):329-43.

[Biochem J. 1993]
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Cited by 7 PubMed Central articles

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