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The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specific tyrosine kinase p56lck and the v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysis revealed that a 3.2-kilobase lyn mRNA was expressed in a variety of tissues of the human fetus. The pattern of lyn mRNA expression was different from those of related genes, such as yes and syn. Hybridization analysis of DNA from sorted chromosomes showed that the lyn gene is located on human chromosome 8 q13-qter.
PMID: 3561390 [PubMed - indexed for MEDLINE]
PMCID: PMC365062
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Cited by 55 PubMed Central articles
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Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.
Kasahara K, Nakayama Y, Ikeda K, Fukushima Y, Matsuda D, Horimoto S, Yamaguchi N.
J Cell Biol. 2004 Jun 7; 165(5):641-52. Epub 2004 Jun 1.
[J Cell Biol. 2004]
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ReviewNatural biology of polyomavirus middle T antigen.
Gottlieb KA, Villarreal LP.
Microbiol Mol Biol Rev. 2001 Jun; 65(2):288-318 ; second and third pages, table of contents.
[Microbiol Mol Biol Rev. 2001]
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Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage.
Yoshida K, Weichselbaum R, Kharbanda S, Kufe D.
Mol Cell Biol. 2000 Aug; 20(15):5370-80.
[Mol Cell Biol. 2000]
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