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Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.
Hirano T,
Yasukawa K,
Harada H,
Taga T,
Watanabe Y,
Matsuda T,
Kashiwamura S,
Nakajima K,
Koyama K,
Iwamatsu A, et al.
When stimulated with antigen, B cells are influenced by T cells to proliferate and differentiate into antibody-forming cells. Since it was reported that soluble factors could replace certain functions of helper T cells in the antibody response, several different kinds of lymphokines and monokines have been reported in B-cell growth and differentiation. Among these, human B-cell differentiation factor (BCDF or BSF-2) has been shown to induce the final maturation of B cells into immunoglobulin-secreting cells. BSF-2 was purified to homogeneity and its partial NH2-terminal amino-acid sequence was determined. These studies indicated that BSF-2 is functionally and structurally unlike other known proteins. Here, we report the molecular cloning, structural analysis and functional expression of the cDNA encoding human BSF-2. The primary sequence of BSF-2 deduced from the cDNA reveals that BSF-2 is a novel interleukin consisting of 184 amino acids.
PMID: 3491322 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Differential baseline and response profile to IFN-gamma gene transduction of IL-6/IL-6 receptor-alpha secretion discriminate primary tumors versus bone marrow metastases of nasopharyngeal carcinomas in culture.
Chou AS, Wang HY, Chen HC, Tsai MH, Chuang CK, Liao SK.
BMC Cancer. 2009 Jun 5; 9:169. Epub 2009 Jun 5.
[BMC Cancer. 2009]
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IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, Vollmar P, Stritesky GL, Kaplan MH, Waisman A, et al.
Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18460-5. Epub 2008 Nov 17.
[Proc Natl Acad Sci U S A. 2008]
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Interleukin-6 in peripheral blood and inflammatory sites in Behçet's disease.
Hamzaoui K, Hamzaoui A, Kahan A, Hamza M, Chabbou A, Ayed K.
Mediators Inflamm. 1992; 1(4):281-5.
[Mediators Inflamm. 1992]
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