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1: Proc Natl Acad Sci U S A. 1986 Jan;83(1):77-81.Click here to read Links

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

Rotwein P.

Through use of a synthetic oligonucleotide probe, human insulin-like growth factor I (IGF-I) cDNA clones were isolated from a liver library. Two types of cDNAs were defined by restriction enzyme analysis and DNA sequencing. Both encode IGF-I precursors of either 195 or 153 amino acids. The two predicted protein precursors are identical from their amino terminus to a lysine residue 16 codons beyond the IGF-I sequence, and then they diverge. Both cDNAs predict additional unique carboxyl-terminal extension peptides. Since there is only one IGF-I gene in the human genome, the finding of two different cDNAs suggests that alternative RNA processing plays a role in IGF-I gene expression. The functions of the different extension peptides remain to be elucidated.

PMID: 3455760 [PubMed - indexed for MEDLINE]

PMCID: PMC322794