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Molecular cloning of human and rat complementary DNA encoding androgen receptors.
Ben May Institute, University of Chicago, IL 60637.
Complementary DNAs (cDNAs) encoding androgen receptors were obtained from human testis and rat ventral prostate cDNA libraries. The amino acid sequence deduced from the nucleotide sequences of the cDNAs indicated the presence of a cysteine-rich DNA-binding domain that is highly conserved in all steroid receptors. The human cDNA was transcribed and the RNA product was translated in cell-free systems to yield a 76-kilodalton protein. The protein was immunoprecipitable by human autoimmune antibodies to the androgen receptor. The protein bound androgens specifically and with high affinity.
PMID: 3353726 [PubMed - indexed for MEDLINE]
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Cited by 61 PubMed Central articles
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Influence of androgen receptor repeat polymorphisms on personality traits in men.
Westberg L, Henningsson S, Landén M, Annerbrink K, Melke J, Nilsson S, Rosmond R, Holm G, Anckarsäter H, Eriksson E.
J Psychiatry Neurosci. 2009 May; 34(3):205-13.
[J Psychiatry Neurosci. 2009]
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Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects.
Szafran AT, Szwarc M, Marcelli M, Mancini MA.
PLoS One. 2008; 3(11):e3605. Epub 2008 Nov 3.
[PLoS One. 2008]
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Androgen receptor is a tumor suppressor and proliferator in prostate cancer.
Niu Y, Altuwaijri S, Lai KP, Wu CT, Ricke WA, Messing EM, Yao J, Yeh S, Chang C.
Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12182-7. Epub 2008 Aug 22.
[Proc Natl Acad Sci U S A. 2008]
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