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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme.
The RAD6 gene of the yeast Saccharomyces cerevisiae is required for a variety of cellular functions including DNA repair. The discovery that the RAD6 gene product can catalyse the covalent attachment of ubiquitin to other proteins suggests that the multiple functions of the RAD6 protein are mediated by its ubiquitin-conjugating activity.
PMID: 3306404 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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A homolog of ScRAD5 is involved in DNA repair and homologous recombination in Arabidopsis.
Chen IP, Mannuss A, Orel N, Heitzeberg F, Puchta H.
Plant Physiol. 2008 Apr; 146(4):1786-96. Epub 2008 Feb 29.
[Plant Physiol. 2008]
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SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system.
Weake VM, Lee KK, Guelman S, Lin CH, Seidel C, Abmayr SM, Workman JL.
EMBO J. 2008 Jan 23; 27(2):394-405. Epub 2008 Jan 10.
[EMBO J. 2008]
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RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Zeng W, Yokomori K, et al.
Mol Cell Biol. 2007 Apr; 27(7):2562-71. Epub 2007 Jan 22.
[Mol Cell Biol. 2007]
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