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Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr.
The leukocyte-common antigen (L-CA or T200) includes a family of lymphoid and myeloid cell surface glycoproteins with apparent molecular weights from 180,000 to 240,000. We report a partial protein sequence for thymocyte L-CA containing 1073 amino acids predicted from cDNA clones isolated using an oligonucleotide probe. Only one segment (residues 347-368) is likely to cross the membrane, and peptide data suggest that sequences N-terminal to this are outside the cell, with residues 369-1073 inside. The cytoplasmic domain includes possible phosphorylation sites and an internal homology between residues 385-671 and 676-986. Analysis of B lymphocyte cDNA clones suggests that B cell and thymocyte mRNAs are identical in 3' sequences, but size differences in Northern blots suggest 5' sequences may differ.
PMID: 3158393 [PubMed - indexed for MEDLINE]
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Cited by 30 PubMed Central articles
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Identification of a receptor-type protein tyrosine phosphatase expressed in postmitotic maturing neurons: its structure and expression in the central nervous system.
Tagawa M, Shirasawa T, Yahagi Y, Tomoda T, Kuroyanagi H, Fujimura S, Sakiyama S, Maruyama N.
Biochem J. 1997 Feb 1; 321 ( Pt 3):865-71.
[Biochem J. 1997]
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Regulation of membrane-associated tyrosine phosphatases in UMR 106.06 osteoblast-like cells.
Southey MC, Findlay DM, Kemp BE.
Biochem J. 1995 Jan 15; 305 ( Pt 2):485-90.
[Biochem J. 1995]
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Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.
Furukawa T, Itoh M, Krueger NX, Streuli M, Saito H.
Proc Natl Acad Sci U S A. 1994 Nov 8; 91(23):10928-32.
[Proc Natl Acad Sci U S A. 1994]
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