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B-raf, a new member of the raf family, is activated by DNA rearrangement.
Department of Oncology, University of Tokyo, Japan.
Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.
PMID: 3043188 [PubMed - indexed for MEDLINE]
PMCID: PMC363468
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Cited by 23 PubMed Central articles
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Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms.
Hmitou I, Druillennec S, Valluet A, Peyssonnaux C, Eychène A.
Mol Cell Biol. 2007 Jan; 27(1):31-43. Epub 2006 Oct 30.
[Mol Cell Biol. 2007]
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Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA, Nikiforov YE.
J Clin Invest. 2005 Jan; 115(1):94-101.
[J Clin Invest. 2005]
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Autoregulation of the Raf-1 serine/threonine kinase.
Cutler RE Jr, Stephens RM, Saracino MR, Morrison DK.
Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9214-9.
[Proc Natl Acad Sci U S A. 1998]
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