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The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of the Picornaviridae.
The genome of the prototype stain of coxsackievirus B4 (J.V.B. Benschoten) has been cloned in Escherichia coli and its complete nucleotide sequence determined. Excluding the poly(A) tract, the RNA genome is 7395 nucleotides in length and appears to encode a single polyprotein of 2183 amino acids. The predicted amino acid sequence of the polyprotein shows close homology (88%) to that of the previously sequenced coxsackievirus B3 and to certain regions of the polyproteins of the polioviruses and human rhinovirus 14. This allows identification of putative polyprotein cleavage signals, antigenic domains and other structural features likely to be important to the biological integrity of the virus.
PMID: 3037008 [PubMed - indexed for MEDLINE]
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Cited by 42 PubMed Central articles
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Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency.
Kanno T, Kim K, Kono K, Drescher KM, Chapman NM, Tracy S.
J Virol. 2006 Jun; 80(11):5637-43.
[J Virol. 2006]
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Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.
Binford SL, Maldonado F, Brothers MA, Weady PT, Zalman LS, Meador JW 3rd, Matthews DA, Patick AK.
Antimicrob Agents Chemother. 2005 Feb; 49(2):619-26.
[Antimicrob Agents Chemother. 2005]
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Recombination in circulating enteroviruses.
Lukashev AN, Lashkevich VA, Ivanova OE, Koroleva GA, Hinkkanen AE, Ilonen J.
J Virol. 2003 Oct; 77(19):10423-31.
[J Virol. 2003]
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