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Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene.
Cell cycle-dependent histone genes are transcribed at a basal level throughout the cell cycle, with a three- to fivefold increase during early S phase. Protein-DNA interactions in the 5' promoter region of a cell cycle-regulated human H4 histone gene have been analyzed at single-nucleotide resolution in vivo. This region contains two sites, with four potential protein-binding domains, at which the DNA is protected from reaction with dimethyl sulfate in cells and from digestion with deoxyribonuclease I in nuclei. These protein-DNA interactions persist during all phases of the cell cycle and dissociate with 0.16 to 0.2M sodium chloride.
PMID: 3035717 [PubMed - indexed for MEDLINE]
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Cited by 38 PubMed Central articles
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Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition.
Xie RL, Liu L, Mitra P, Stein JL, van Wijnen AJ, Stein GS.
Gene. 2007 Nov 1; 402(1-2):94-102. Epub 2007 Aug 9.
[Gene. 2007]
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The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT.
Medina R, van Wijnen AJ, Stein GS, Stein JL.
Biochemistry. 2006 Dec 26; 45(51):15915-20.
[Biochemistry. 2006]
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HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.
Miele A, Braastad CD, Holmes WF, Mitra P, Medina R, Xie R, Zaidi SK, Ye X, Wei Y, Harper JW, et al.
Mol Cell Biol. 2005 Jul; 25(14):6140-53.
[Mol Cell Biol. 2005]
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