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The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus.
The complete 606 amino acid sequence of the human A-raf oncogene has been deduced from the 2453 nucleotide sequence of a human T cell cDNA. A cysteine-rich region located near the amino terminus, which is highly conserved in A-raf and c-raf, shows significant homology with protein kinase C. A 5' deleted fragment of the cDNA has been incorporated into a murine retrovirus which endows the virus with the ability to transform cells in vivo and in vitro. Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function.
PMID: 3029685 [PubMed - indexed for MEDLINE]
PMCID: PMC340454
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Cited by 31 PubMed Central articles
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Analysis of canonical and non-canonical splice sites in mammalian genomes.
Burset M, Seledtsov IA, Solovyev VV.
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[Nucleic Acids Res. 2000]
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Autoregulation of the Raf-1 serine/threonine kinase.
Cutler RE Jr, Stephens RM, Saracino MR, Morrison DK.
Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9214-9.
[Proc Natl Acad Sci U S A. 1998]
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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers.
Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, et al.
EMBO J. 1998 Jun 1; 17(11):3052-65.
[EMBO J. 1998]
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