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The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5' leader.
The Ace locus of Drosophila melanogaster has been mapped at the molecular level. cDNA clones from the locus have been isolated and their sequence determined, confirming that Ace forms the structural gene for acetylcholinesterase (AChE). The cDNAs have a 1950 nucleotide open reading frame from which the complete amino acid sequence of AChE has been deduced. The Drosophila enzyme is found to have extensive homology to the known sequence of Torpedo AChE. Ace cDNAs have an unusual structure with a long 5' leader and several short upstream open reading frames.
PMID: 3024971 [PubMed - indexed for MEDLINE]
PMCID: PMC1167246
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Cited by 32 PubMed Central articles
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The effect of engineered disulfide bonds on the stability of Drosophila melanogaster acetylcholinesterase.
Siadat OR, Lougarre A, Lamouroux L, Ladurantie C, Fournier D.
BMC Biochem. 2006 Apr 16; 7:12. Epub 2006 Apr 16.
[BMC Biochem. 2006]
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A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non-homologous to the ace gene in Drosophila.
Weill M, Fort P, Berthomieu A, Dubois MP, Pasteur N, Raymond M.
Proc Biol Sci. 2002 Oct 7; 269(1504):2007-16.
[Proc Biol Sci. 2002]
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Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine.
Fremaux I, Mazères S, Brisson-Lougarre A, Arnaud M, Ladurantie C, Fournier D.
BMC Biochem. 2002 Jul 30; 3:21. Epub 2002 Jul 30.
[BMC Biochem. 2002]
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