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The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.
We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.
PMID: 3024106 [PubMed - indexed for MEDLINE]
PMCID: PMC311868
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Cited by 9 PubMed Central articles
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Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.
Marenholz I, Zirra M, Fischer DF, Backendorf C, Ziegler A, Mischke D.
Genome Res. 2001 Mar; 11(3):341-55.
[Genome Res. 2001]
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The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing.
Wieczorek DF, Smith CW, Nadal-Ginard B.
Mol Cell Biol. 1988 Feb; 8(2):679-94.
[Mol Cell Biol. 1988]
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Human hTM alpha gene: expression in muscle and nonmuscle tissue.
MacLeod AR, Gooding C.
Mol Cell Biol. 1988 Jan; 8(1):433-40.
[Mol Cell Biol. 1988]
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