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Theiler's virus genome is closely related to that of encephalomyocarditis virus, the prototype cardiovirus.
Theiler's virus causes a persistent demyelinating infection of the mouse central nervous system. Our study of the molecular mechanism of persistence led us to sequence 1925 nucleotides located at the 3' end of the viral genome. We observed extensive homologies between this region and the corresponding region of encephalomyocarditis virus, the prototype cardiovirus, and only some homologies with the 3' ends of foot-and-mouth disease virus, rhinovirus, and poliovirus genomes.
PMID: 3023668 [PubMed - indexed for MEDLINE]
PMCID: PMC253377
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Cited by 18 PubMed Central articles
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ReviewTheiler's virus infection: a model for multiple sclerosis.
Oleszak EL, Chang JR, Friedman H, Katsetos CD, Platsoucas CD.
Clin Microbiol Rev. 2004 Jan; 17(1):174-207.
[Clin Microbiol Rev. 2004]
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Sialylation of the host receptor may modulate entry of demyelinating persistent Theiler's virus.
Zhou L, Luo Y, Wu Y, Tsao J, Luo M.
J Virol. 2000 Feb; 74(3):1477-85.
[J Virol. 2000]
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The GDVII strain of Theiler's virus spreads via axonal transport.
Martinat C, Jarousse N, Prévost MC, Brahic M.
J Virol. 1999 Jul; 73(7):6093-8.
[J Virol. 1999]
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