Your browser version may not work well with NCBI's Web applications. More information here...
1: Nucleic Acids Res. 1986 Feb 11;14(3):1379-91.Click here to read Click here to read Links

Nucleotide sequence of the chicken 5-aminolevulinate synthase gene.

Maguire DJ, Day AR, Borthwick IA, Srivastava G, Wigley PL, May BK, Elliott WH.

5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 bp from the 5' flanking region including 34 bp of the first exon shows promoter activity when introduced upstream of a chicken histone H2B gene and injected into the nuclei of Xenopus laevis oocytes.

PMID: 3005973 [PubMed - indexed for MEDLINE]

PMCID: PMC339511