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Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II.
The Drosophila melanogaster RpII215 locus encodes the largest subunit of RNA polymerase II. We have now mapped the 7 kb transcript of the locus and have determined that it contains four exons and three introns. By sequencing 2582 nucleotides from the promoter-proximal end of the RpII215 locus, we have precisely mapped the start site of transcription and the splice sites of the first intron. Segments of the amino acid sequence predicted by the only long open reading frame of the RpII215 gene transcript display striking homology with corresponding segments of the beta subunit of E. coli RNA polymerase.
PMID: 2992806 [PubMed - indexed for MEDLINE]
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Cited by 40 PubMed Central articles
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Isolation of Amatoxin-Resistant Lines of Chlamydomonas reinhardtii: Evidence for RNA Polymerase Mutants.
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[Plant Physiol. 1988]
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Cloning and identification of the gene coding for the 140-kd subunit of Drosophila RNA polymerase II.
Faust DM, Renkawitz-Pohl R, Falkenburg D, Gasch A, Bialojan S, Young RA, Bautz EK.
EMBO J. 1986 Apr; 5(4):741-746.
[EMBO J. 1986]
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Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization.
Chen HK, Pai CY, Huang JY, Yeh NH.
Mol Cell Biol. 1999 Dec; 19(12):8536-46.
[Mol Cell Biol. 1999]
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