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Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.
Transformation of fibroblasts by protooncogene fos (c-fos) requires the linkage of viral long terminal repeat (LTR) sequences and interruption of 3'-noncoding sequences. We have identified an A + T-rich stretch of 67 nucleotides, located 627-693 base pairs downstream from the coding domain and 123-189 base pairs upstream from the putative poly(A) addition site, removal of which confers transforming activity to the c-fos gene. A novel regulation of the expression of the c-fos gene is proposed, which may be functional in vivo to prevent the gene from becoming an oncogene.
PMID: 2991903 [PubMed - indexed for MEDLINE]
PMCID: PMC390483
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Cited by 56 PubMed Central articles
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Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Mazan-Mamczarz K, Hagner PR, Corl S, Srikantan S, Wood WH, Becker KG, Gorospe M, Keene JD, Levenson AS, Gartenhaus RB.
Oncogene. 2008 Oct 16; 27(47):6151-63. Epub 2008 Jul 21.
[Oncogene. 2008]
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Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1.
Paschoud S, Dogar AM, Kuntz C, Grisoni-Neupert B, Richman L, Kühn LC.
Mol Cell Biol. 2006 Nov; 26(22):8228-41. Epub 2006 Sep 5.
[Mol Cell Biol. 2006]
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ReviewAU-rich elements and associated factors: are there unifying principles?
Barreau C, Paillard L, Osborne HB.
Nucleic Acids Res. 2005; 33(22):7138-50. Epub 2006 Jan 3.
[Nucleic Acids Res. 2005]
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