The human vasopressin gene is linked to the oxytoc...[J Biol Chem. 1985]

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1: J Biol Chem. 1985 Aug 25;260(18):10236-41. Links

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

Sausville E, Carney D, Battey J.

The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.

PMID: 2991279 [PubMed - indexed for MEDLINE]

Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20.
Mol Endocrinol. 1990 Jun; 4(6):947-50.

[Mol Endocrinol. 1990]
Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence.
Nature. 1984 Apr 5-11; 308(5959):554-7.

[Nature. 1984]
Provasopressin-neurophysin II processing is cell-specific in heterologous cell lines expressing a metallothionein-vasopressin fusion gene.
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[J Biol Chem. 1987]
ReviewMolecular biology of diabetes insipidus.
Annu Rev Med. 1995; 46:331-43.

[Annu Rev Med. 1995]
ReviewThe use of linkage analysis and the Centre d'Etude Polymorphisme Humain (CEPH) panel of DNA in the study of the arginine vasopressin, oxytocin and prodynorphin gene loci.
Prog Brain Res. 1992; 93:309-17.

[Prog Brain Res. 1992]
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Cited by 23 PubMed Central articles

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