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Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.
March CJ,
Mosley B,
Larsen A,
Cerretti DP,
Braedt G,
Price V,
Gillis S,
Henney CS,
Kronheim SR,
Grabstein K, et al.
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.
PMID: 2989698 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Regulation of electrolyte transport with IL-1beta in rabbit distal colon.
Homaidan FR, Desai H, Zhao L, Broutman G, Burakoff R.
Mediators Inflamm. 1995; 4(1):61-6.
[Mediators Inflamm. 1995]
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Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer.
Kumar S, Kishimoto H, Chua HL, Badve S, Miller KD, Bigsby RM, Nakshatri H.
Am J Pathol. 2003 Dec; 163(6):2531-41.
[Am J Pathol. 2003]
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Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells.
Madrigal-Estebas L, Doherty DG, O'Donoghue DP, Feighery C, O'Farrelly C.
Mediators Inflamm. 2002 Oct; 11(5):313-9.
[Mediators Inflamm. 2002]
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