-
Molecular cloning and complete sequence determination of RNA genome of human rhinovirus type 14.
The genomic RNA of human rhinovirus type 14 was cloned in Escherichia coli and the complete nucleotide sequence was determined. The RNA genome is 7212 nucleotides long. A single large open reading frame of 6536 nucleotides was identified, which starts at nucleotide 678 and ends 47 nucleotides from the 3' end of the RNA genome. Comparisons of the specified proteins with those of other picornaviruses showed a striking homology (44-65%) between rhinovirus and poliovirus. The rhinovirus genomic RNA is rich in adenosine (32.1%) and strongly favors an adenosine or uridine in the third position of codons. The predicted map locations of all the rhinovirus structural and non-structural proteins and their proposed proteolytic cleavage sites are described.
PMID: 2983312 [PubMed - indexed for MEDLINE]
PMCID: PMC397120
-
Cited by 42 PubMed Central articles
-
A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants.
Lee WM, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T, Jakiela B, Lemanske RF Jr, Shult PA, Gern JE.
PLoS One. 2007 Oct 3; 2(10):e966. Epub 2007 Oct 3.
[PLoS One. 2007]
-
Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children.
Lau SK, Yip CC, Tsoi HW, Lee RA, So LY, Lau YL, Chan KH, Woo PC, Yuen KY.
J Clin Microbiol. 2007 Nov; 45(11):3655-64. Epub 2007 Sep 5.
[J Clin Microbiol. 2007]
-
New complete genome sequences of human rhinoviruses shed light on their phylogeny and genomic features.
Tapparel C, Junier T, Gerlach D, Cordey S, Van Belle S, Perrin L, Zdobnov EM, Kaiser L.
BMC Genomics. 2007 Jul 10; 8:224. Epub 2007 Jul 10.
[BMC Genomics. 2007]
- » See all...