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A variation in the structure of the protein-coding region of the human p53 gene.
Institute of Molecular Biology, U.S.S.R. Academy of Sciences, Moscow.
An extensive analysis of genomic DNA preparations from a number of normal and malignant tissues revealed BglII site polymorphism of the human p53 gene. Approximately 10% of p53 gene alleles were found to contain an additional BglII site localized in a region of intron I. This allelic form of p53 gene was also responsible for p53 protein having altered electrophoretic mobility. Molecular cloning and sequencing of both the alleles of p53 gene revealed a base-pair change in codon 72 causing arginine----proline substitution in the allele with the additional BglII site. Both variants of the p53 gene may occur in homozygous state and are therefore functional.
PMID: 2905688 [PubMed - indexed for MEDLINE]
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Cited by 26 PubMed Central articles
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Telomerase activity, P53 mutation and Ki-ras codon 12 point mutation of the peripheral blood in patients with hepato pancreato biliary diseases.
Yamaguchi K, Chijiiwa K, Torata N, Kinoshita M, Tanaka M.
HPB (Oxford). 2002; 4(2):75-82.
[HPB (Oxford). 2002]
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Altered p53 in microdissected, metachronous, premalignant and malignant oral lesions from the same patients.
Li YQ, Pavelic ZP, Wang LJ, McDonald JS, Gleich L, Munck-Wikland E, Dacic S, Danilovic Z, Pavelic LJ, Wilson KM, et al.
Clin Mol Pathol. 1995 Oct; 48(5):M269-M272.
[Clin Mol Pathol. 1995]
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Preparation of DNA-modified nanoparticles and preliminary study for colorimetric SNP analysis using their selective aggregations.
Ihara T, Tanaka S, Chikaura Y, Jyo A.
Nucleic Acids Res. 2004 Jul 14; 32(12):e105. Epub 2004 Jul 14.
[Nucleic Acids Res. 2004]
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