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A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
PMID: 2869410 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells.
Scheper MA, Shirtliff ME, Meiller TF, Peters BM, Jabra-Rizk MA.
Neoplasia. 2008 Sep; 10(9):954-63.
[Neoplasia. 2008]
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Lip, a human gene detected by transfection of DNA from a human liposarcoma encodes a protein with homology to regulators of small g proteins.
Patterson H, Gill S, Benjamin H, Mitchell PJ, Cooper CS.
Sarcoma. 1998; 2(1):35-44.
[Sarcoma. 1998]
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Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.
Reuther GW, Lambert QT, Caligiuri MA, Der CJ.
Mol Cell Biol. 2000 Dec; 20(23):8655-66.
[Mol Cell Biol. 2000]
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