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A constitutive promoter directs expression of the nerve growth factor receptor gene.
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021.
Expression of nerve growth factor receptor is normally restricted to cells derived from the neural crest in a developmentally regulated manner. We analyzed promoter sequences for the human nerve growth factor receptor gene and found that the receptor promoter resembles others which are associated with constitutively expressed genes that have housekeeping and growth-related functions. Unlike these other genes, the initiation of transcription occurred at one major site rather than at multiple sites. The constitutive nature of the nerve growth factor receptor promoter may account for the ability of this gene to be transcribed in a diverse number of heterologous cells after gene transfer. The intron-exon structure of the receptor gene indicated that structural features are precisely divided into discrete domains.
PMID: 2850481 [PubMed - indexed for MEDLINE]
PMCID: PMC363544
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Cited by 42 PubMed Central articles
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The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.
Hsu LC, Liu S, Abedinpour F, Beech RD, Lahti JM, Kidd VJ, Greenspan JA, Yeung CY.
Mol Cell Biol. 2003 Dec; 23(23):8773-85.
[Mol Cell Biol. 2003]
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Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment.
Chan H, Bartos DP, Owen-Schaub LB.
Mol Cell Biol. 1999 Mar; 19(3):2098-108.
[Mol Cell Biol. 1999]
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Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor alpha 2 subunit gene.
Bessis A, Savatier N, Devillers-Thiéry A, Bejanin S, Changeux JP.
Nucleic Acids Res. 1993 May 11; 21(9):2185-92.
[Nucleic Acids Res. 1993]
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