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The complete nucleotide sequence of the genome of a hepatitis B virus isolated from a naturally infected chimpanzee.
Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, U.K.
The complete nucleotide sequence of a strain of hepatitis B virus, originally isolated from a naturally infected chimpanzee, has been determined. Interesting features of the sequence include the presence of an in-phase stop codon in the 'pre-core' region of the core antigen open reading frame. The sequence shows approximately 10% nucleotide divergence from all of the other hepatitis B virus sequences previously published and the possibility that this divergence is the result of passage through chimpanzees is discussed.
PMID: 2838576 [PubMed - indexed for MEDLINE]
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Cited by 20 PubMed Central articles
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