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Nucleotide sequence of the androgen-dependent arginine esterase mRNA of canine prostate.
Laboratory of Hormonal Bioregulation, Laval University Hospital Centre, Sainte-Foy, Québec, Canada.
The nucleotide sequence of canine prostate arginine esterase mRNA was determined using a 400 bp cDNA clone and primer-extended cDNA transcripts for the 5'-coding and noncoding regions. The mRNA contains 864 nucleotides encoding a protein of 236 amino acids preceded by 24 amino acids which constitutes both the signal and the zymogen peptides. The sequence indicates the presence of one potential glycosylation site. A high degree of homology was found between the canine enzyme and other members of the kallikrein family including human prostate specific antigen. The protein appears to be specified by a single gene.
PMID: 2835268 [PubMed - indexed for MEDLINE]
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