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Organisation of the regulatory region of the Escherichia coli melibiose operon.
Department of Biochemistry, University of Birmingham, U.K.
The regulatory region of the Escherichia coli melibiose operon contains two divergent promoters. One promoter is responsible for the expression of the melR gene, that is essential for melibiose-dependent stimulation of the second promoter. Melibiose-induced transcription from this second promoter initiates at a start point 25 bp upstream from the start codon of the melA gene, encoding an alpha-galactosidase. The nucleotide sequence covering the divergent promoters and the melR gene is reported.
PMID: 2830169 [PubMed - indexed for MEDLINE]
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Cited by 28 PubMed Central articles
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Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR.
Samarasinghe S, El-Robh MS, Grainger DC, Zhang W, Soultanas P, Busby SJ.
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[Nucleic Acids Res. 2008]
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Mutational analysis of the Escherichia coli melR gene suggests a two-state concerted model to explain transcriptional activation and repression in the melibiose operon.
Kahramanoglou C, Webster CL, El-Robh MS, Belyaeva TA, Busby SJ.
J Bacteriol. 2006 May; 188(9):3199-207.
[J Bacteriol. 2006]
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Genomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays.
Grainger DC, Overton TW, Reppas N, Wade JT, Tamai E, Hobman JL, Constantinidou C, Struhl K, Church G, Busby SJ.
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[J Bacteriol. 2004]
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