Molecular cloning of complementary DNA for human m...[J Biochem. 1987]

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1: J Biochem. 1987 Jul;102(1):13-6. Links

Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells.

Okano K, Aoki Y, Sakurai T, Kajitani M, Kanai S, Shimazu T, Shimizu H, Naruto M.

Basic Research Laboratories, Toray Industries, Inc., Kanagawa.

Medullasin, an inflammatory serine protease in bone marrow cells, modifies the functions of natural killer cells, monocytes, and granulocytes. We have cloned a medullasin cDNA from a human acute promyelocytic cell (ML3) cDNA library using oligonucleotide probes synthesized from the information of N-terminal amino acid sequence of natural medullasin. The cDNA contained a long open reading frame encoding 237 amino acid residues beginning from the second amino acid of natural meduallasin. The deduced amino acid sequence of medullasin shows a typical serine protease structure, with 41% homology with pig elastase 1.

PMID: 2822677 [PubMed - indexed for MEDLINE]

The primary structure and elastinolytic activity of medullasin (a serine protease of bone marrow).
Biochem Biophys Res Commun. 1991 Jul 31; 178(2):501-6.

[Biochem Biophys Res Commun. 1991]
Functional expression of human leukocyte elastase (HLE)/medullasin in eukaryotic cells.
Biochem Biophys Res Commun. 1990 Mar 30; 167(3):1326-32.

[Biochem Biophys Res Commun. 1990]
Low molecular weight peptide inhibitors of medullasin: purification and structure.
J Enzyme Inhib. 1990; 3(4):279-87.

[J Enzyme Inhib. 1990]
Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.
J Immunol. 1991 Nov 1; 147(9):3210-4.

[J Immunol. 1991]
ReviewHuman neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases.
Adv Exp Med Biol. 1991; 305:89-96.

[Adv Exp Med Biol. 1991]
» See reviews... | » See all...

Cited by 3 PubMed Central articles

Nucleotide sequence of human bone marrow serine protease (medullasin) gene.
Nakamura H, Okano K, Aoki Y, Shimizu H, Naruto M. Nucleic Acids Res. 1987 Nov 25; 15(22):9601-2.

[Nucleic Acids Res. 1987]
CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.
Pereira HA, Shafer WM, Pohl J, Martin LE, Spitznagel JK. J Clin Invest. 1990 May; 85(5):1468-76.

[J Clin Invest. 1990]
Induction of activated killer cells from human lymphocytes by medullasin (a serine protease in bone marrow cells).
Aoki Y, Hase T, Oshimi K, Suzuki K. Immunology. 1992 Mar; 75(3):481-7.

[Immunology. 1992]

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Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells.

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Cited by 3 PubMed Central articles

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