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The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.
Institute für Genetik, Universität Köln, FRG.
Alzheimer's disease (AD) is characterized by the cerebral deposition of fibrillar aggregates of the amyloid A4 protein. Complementary DNA's coding for the precursor of the amyloid A4 protein have been described. In order to identify the structure of the precursor gene relevant clones from several human genomic libraries were isolated. Sequence analysis of the various clones revealed 16 exons to encode the 695 residue precursor protein (PreA4(695] of Alzheimer's disease amyloid A4 protein. The DNA sequence coding for the amyloid A4 protein is interrupted by an intron. This finding supports the idea that amyloid A4 protein arises by incomplete proteolysis of a larger precursor, and not by aberrant splicing.
PMID: 2783775 [PubMed - indexed for MEDLINE]
PMCID: PMC331600
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Cited by 11 PubMed Central articles
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Ribozyme mediated degradation of beta-amyloid peptide precursor mRNA in COS-7 cells.
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[Nucleic Acids Res. 1994]
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ReviewGenetic dissection of Alzheimer disease, a heterogeneous disorder.
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Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8552-9.
[Proc Natl Acad Sci U S A. 1995]
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Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.
Wirak DO, Bayney R, Kundel CA, Lee A, Scangos GA, Trapp BD, Unterbeck AJ.
EMBO J. 1991 Feb; 10(2):289-96.
[EMBO J. 1991]
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