Full length cDNA structure and deduced amino acid ...[Mol Endocrinol. 1989]

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1: Mol Endocrinol. 1989 Aug;3(8):1310-2. Links

Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase.

Luu The V, Lachance Y, Labrie C, Leblanc G, Thomas JL, Strickler RC, Labrie F.

Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada.

Polyclonal antibodies raised against 3 beta-hydroxysteroid dehydrogenase isolated from human placenta were used to screen a lambda gt11 expression cDNA library from the same tissue. The protein deduced from cDNA sequences contains 372 amino acids with a calculated mol wt of 42,216. Since 3 beta-hydroxysteroid dehydrogenase is the enzyme catalyzing the formation of all classes of hormonal steroids, the availability of the cDNA encoding this enzyme opens new possibilities for a detailed investigation of the factors regulating the expression and activity of this crucial enzyme in adrenal, gonadal as well as peripheral tissues.

PMID: 2779585 [PubMed - indexed for MEDLINE]

Characterization of macaque 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate.
Mol Cell Endocrinol. 1991 Feb; 75(2):101-10.

[Mol Cell Endocrinol. 1991]
Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta.
Mol Endocrinol. 1989 Aug; 3(8):1301-9.

[Mol Endocrinol. 1989]
Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase.
J Reprod Fertil. 1991 Sep; 93(1):149-56.

[J Reprod Fertil. 1991]
ReviewThe multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression.
Steroids. 1997 Jan; 62(1):169-75.

[Steroids. 1997]
ReviewStructure, regulation and role of 3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues.
Baillieres Clin Endocrinol Metab. 1994 Apr; 8(2):451-74.

[Baillieres Clin Endocrinol Metab. 1994]
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Cited by 6 PubMed Central articles

Immature cryopreserved ovary restores puberty and fertility in mice without alteration of epigenetic marks.
Sauvat F, Capito C, Sarnacki S, Poirot C, Bachelot A, Meduri G, Dandolo L, Binart N. PLoS One. 2008 Apr 16; 3(4):e1972. Epub 2008 Apr 16.

[PLoS One. 2008]
gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus.
Do-Rego JL, Mensah-Nyagan GA, Beaujean D, Vaudry D, Sieghart W, Luu-The V, Pelletier G, Vaudry H. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13925-30.

[Proc Natl Acad Sci U S A. 2000]
A common ancestor for mammalian 3 beta-hydroxysteroid dehydrogenase and plant dihydroflavonol reductase.
Baker ME, Luu-The Y, Simard J, Labrie F. Biochem J. 1990 Jul 15; 269(2):558-9.

[Biochem J. 1990]
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