Three-dimensional structure of human serum albumin. [Science. 1989]

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1: Science. 1989 Jun 9;244(4909):1195-8. Links

Three-dimensional structure of human serum albumin.

Carter DC, He XM, Munson SH, Twigg PD, Gernert KM, Broom MB, Miller TY.

National Aeronautics and Space Administration, Space Sciences Laboratory, Marshall Space Flight Center, AL 35812.

The three-dimensional structure of human serum albumin has been solved at 6.0 angstrom (A) resolution by the method of multiple isomorphous replacement. Crystals were grown from solutions of polyethylene glycol in the infrequently observed space group P42(1)2 (unit cell constants a = b = 186.5 +/- 0.5 A and c = 81.0 +/- 0.5 A) and diffracted x-rays to lattice d-spacings of less than 2.9 A. The electron density maps are of high quality and revealed the structure as a predominantly alpha-helical globin protein in which the course of the polypeptide can be traced. The binding loci of several organic compounds have been determined.

PMID: 2727704 [PubMed - indexed for MEDLINE]

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Structures reported by this article

X-Ray Study Of Recombinant Human Serum Albumin. Phases Determined By Molecular Replacement Method, Using Low Resolution Structure Model Of Tetragonal Form Of Human Serum Albumin

PDB: 1UOR

Source: Homo sapiens

Method: X-Ray Diffraction | Resolution: 2.8 Å
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