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Structure of the low-density lipoprotein receptor-related protein (LRP) promoter.
European Molecular Biology Laboratory, Heidelberg, F.R.G.
The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.
PMID: 2597675 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells.
Azhar S, Medicherla S, Shen WJ, Fujioka Y, Fong LG, Reaven E, Cooper AD.
J Lipid Res. 2006 Nov; 47(11):2538-50. Epub 2006 Aug 23.
[J Lipid Res. 2006]
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New nucleotide sequence data on the EMBL File Server.
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Nucleic Acids Res. 1990 Mar 11; 18(5):1321-30.
[Nucleic Acids Res. 1990]
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Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.
Shimano H, Yamada N, Katsuki M, Shimada M, Gotoda T, Harada K, Murase T, Fukazawa C, Takaku F, Yazaki Y.
Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1750-4.
[Proc Natl Acad Sci U S A. 1992]
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