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1: Biochemistry. 1989 Jan 24;28(2):651-6.Links

Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure.

Hui Bon Hoa G, Di Primo C, Dondaine I, Sligar SG, Gunsalus IC, Douzou P.

INSERM-INRA, U310, Institut de Biologie Physico-Chimique, Paris, France.

Absorbance and fluorescence spectra of bacterial cytochrome P-450cam and cytochrome P-450lin have been studied as a function of pressure. These pressure-induced spectral perturbations fall into two categories, which are interpreted as resulting from denaturation domains and are discussed in terms of protein structural dynamics. The results presented herein support a view that these two bacterial cytochromes have large structural differences and suggest a picture in which the gellike cortex of each protein may play an essential role in stability and function.

PMID: 2578028 [PubMed - indexed for MEDLINE]