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Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.
Cold Spring Harbor Laboratory, New York 11724.
Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.
PMID: 2552322 [PubMed - indexed for MEDLINE]
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Cited by 83 PubMed Central articles
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Functional Implications in Apoptosis by Interferon Inducible Gene Product 1-8D, the Binding Protein to Adenovirus Preterminal Protein.
Joung I, Angeletti PC, Engler JA.
J Microbiol. 2003; 41(4):295-9.
[J Microbiol. 2003]
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Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.
Fradet-Turcotte A, Vincent C, Joubert S, Bullock PA, Archambault J.
J Virol. 2007 Sep; 81(17):9162-74. Epub 2007 Jun 27.
[J Virol. 2007]
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Phosphorylation mutants of JC virus agnoprotein are unable to sustain the viral infection cycle.
Sariyer IK, Akan I, Palermo V, Gordon J, Khalili K, Safak M.
J Virol. 2006 Apr; 80(8):3893-903.
[J Virol. 2006]
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