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Cloning and sequence determination of human placental aldose reductase gene.
Department of Biological Chemistry, University of Illinois, Chicago 60612.
The human aldose reductase gene has been cloned by screening a human placental cDNA library with antibodies against bovine lens aldose reductase. The nucleotide sequence of the entire coding region has been determined. The deduced amino acid sequence indicates that the human enzyme is 84% identical to the bovine lens aldose reductase and 85% identical to the rat lens aldose reductase. It is also very similar to the human aldehyde reductase, the bovine prostaglandin F synthase, and to the European common frog rho-crystallin. The deduced amino acid sequence also indicates that maturation of aldose reductase involves removal of the N-terminal methionine.
PMID: 2504709 [PubMed - indexed for MEDLINE]
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Cited by 12 PubMed Central articles
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Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5' end of the aldose reductase gene.
Heesom AE, Millward A, Demaine AG.
J Neurol Neurosurg Psychiatry. 1998 Feb; 64(2):213-6.
[J Neurol Neurosurg Psychiatry. 1998]
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ReviewComparative anatomy of the aldo-keto reductase superfamily.
Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM.
Biochem J. 1997 Sep 15; 326 ( Pt 3):625-36.
[Biochem J. 1997]
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Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.
Lau ET, Cao D, Lin C, Chung SK, Chung SS.
Biochem J. 1995 Dec 1; 312 ( Pt 2):609-15.
[Biochem J. 1995]
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