-
Amino-acid sequence of human alpha 2-antiplasmin.
The amino-acid sequence of human alpha 2-antiplasmin was determined by Edman degradation of peptides purified from CNBr, tryptic and chymotryptic digests. Of the total sequence of 452 amino acids of mature alpha 2-antiplasmin, as deduced from the cDNA sequence [Holmes et al. (1987) J. Biol. Chem. 262, 1659-1664], 444 residues were identified by amino-acid sequencing. Two differences were found between the peptide and cDNA analyses (Gly instead of Leu at position 10 and Gly instead of Ser at position 369). alpha 2-Antiplasmin contains two disulfide bridges (Cys64-Cys104 and Cys31-Cys113) and four glucosamine-based carbohydrate chains attached to Asn87, Asn256, Asn270 and Asn277. alpha 2-Antiplasmin is homologous with 12 other proteins belonging to the serine protease inhibitor (serpin) superfamily.
PMID: 2440681 [PubMed - indexed for MEDLINE]
-
Cited by 5 PubMed Central articles
-
Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties.
Christensen S, Valnickova Z, Thogersen IB, Olsen EH, Enghild JJ.
Biochem J. 1997 May 1; 323 ( Pt 3):847-52.
[Biochem J. 1997]
-
Different N-terminal forms of alpha 2-plasmin inhibitor in human plasma.
Bangert K, Johnsen AH, Christensen U, Thorsen S.
Biochem J. 1993 Apr 15; 291 ( Pt 2):623-5.
[Biochem J. 1993]
-
Alpha 2-antiplasmin Enschede is not an inhibitor, but a substrate, of plasmin.
Rijken DC, Groeneveld E, Kluft C, Nieuwenhuis HK.
Biochem J. 1988 Oct 15; 255(2):609-15.
[Biochem J. 1988]
- » See all...