-
A transposable epitope of HLA-B7, B40 molecules.
The monoclonal antibody MB40.2 defines a novel subtype of HLA-B40 that is expressed by the Sweig cell line. This molecule, called HLA-B40, lacks an antigenic determinant that is common to HLA-B7 and the HLA-Bw60 subtype of HLA-B40. Genes encoding HLA-B40 and HLA-Bw60 have now been isolated and the amino acid sequences of these proteins compared with other HLA-B locus molecules. These results show that HLA-B40 is a unique protein which differs from HLA-Bw60 by eight amino acid substitutions. Comparison of the sequences for HLA-B40, -Bw60, and -B7 localizes the MB40.2 epitope to a cluster of three substitutions at positions 177, 178, and 180 at the end of the alpha 2 domain. Gene conversion or reciprocal recombination are postulated to have transferred this cluster of substitutions, and their associated epitope, during the evolution of HLA-B locus genes. The epitope may consist of an alpha helical segment which is exclusively found on MB40.2-positive molecules.
PMID: 2437025 [PubMed - indexed for MEDLINE]
-
Cited by 2 PubMed Central articles
-
Nature of polymorphism in HLA-A, -B, and -C molecules.
Parham P, Lomen CE, Lawlor DA, Ways JP, Holmes N, Coppin HL, Salter RD, Wan AM, Ennis PD.
Proc Natl Acad Sci U S A. 1988 Jun; 85(11):4005-9.
[Proc Natl Acad Sci U S A. 1988]
-
Nucleotide sequences of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution.
Mayer WE, Jonker M, Klein D, Ivanyi P, van Seventer G, Klein J.
EMBO J. 1988 Sep; 7(9):2765-74.
[EMBO J. 1988]