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Characterization of cDNA clones for the human c-yes gene.
Three c-yes cDNA clones were obtained from poly(A)+ RNA of human embryo fibroblasts. Sequence analysis of the clones showed that they contained inserts corresponding to nearly full-length human c-yes mRNA, which could encode a polypeptide of 543 amino acids with a relative molecular weight (Mr) of 60,801. The predicted amino acid sequence of the protein has no apparent membrane-spanning region or suspected ligand binding domain and closely resembles pp60c-src. Comparison of the sequences of c-yes and v-yes revealed that the v-yes gene contains most of the c-yes coding sequence except the region encoding its extreme carboxyl terminus. The region missing from the v-yes protein is the part that is highly conserved in cellular gene products of the protein-tyrosine kinase family.
PMID: 2436037 [PubMed - indexed for MEDLINE]
PMCID: PMC365039
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Cited by 40 PubMed Central articles
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The Src family kinase c-Yes is required for maturation of West Nile virus particles.
Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI, Nelson JA.
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[J Virol. 2005]
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Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data.
Muro S, Takemasa I, Oba S, Matoba R, Ueno N, Maruyama C, Yamashita R, Sekimoto M, Yamamoto H, Nakamori S, et al.
Genome Biol. 2003; 4(3):R21. Epub 2003 Feb 27.
[Genome Biol. 2003]
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Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells.
Chen YH, Lu Q, Goodenough DA, Jeansonne B.
Mol Biol Cell. 2002 Apr; 13(4):1227-37.
[Mol Biol Cell. 2002]
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