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Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence.
Clones carrying cDNA sequences for the alpha-subunit of the Na,K-ATPase from HeLa cells have been isolated. Nucleotide sequence analysis of the cloned cDNA has revealed the primary structure of this polypeptide, which consists of 1,023 amino acids. The alpha-subunit of the human Na,K-ATPase exhibited 87% homology with its Torpedo counterpart and 98% homology with its sheep counterpart. The six putative transmembrane segments M1-M6 showed higher conservation than the total segments. Total genomic Southern hybridization indicated the existence of at most two copies, possibly only one, of the gene encoding the Na,K-ATPase alpha-subunit in the human genome.
PMID: 2430951 [PubMed - indexed for MEDLINE]
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Cited by 15 PubMed Central articles
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Isoform specificity of human Na(+), K(+)-ATPase localization and aldosterone regulation in mouse kidney cells.
Summa V, Camargo SM, Bauch C, Zecevic M, Verrey F.
J Physiol. 2004 Mar 1; 555(Pt 2):355-64. Epub 2003 Dec 23.
[J Physiol. 2004]
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Molecular and functional studies of electrogenic Na(+) transport in the distal colon and rectum of young and elderly subjects.
Greig ER, Mathialahan T, Boot-Handford RP, Sandle GI.
Gut. 2003 Nov; 52(11):1607-15.
[Gut. 2003]
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Apical plasma membrane mispolarization of NaK-ATPase in polycystic kidney disease epithelia is associated with aberrant expression of the beta2 isoform.
Wilson PD, Devuyst O, Li X, Gatti L, Falkenstein D, Robinson S, Fambrough D, Burrow CR.
Am J Pathol. 2000 Jan; 156(1):253-68.
[Am J Pathol. 2000]
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Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...