-
Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients.
To define further the genetic variability of the human AIDS retrovirus, we have cloned and sequenced the complete genomes of two isolates obtained from Zairian patients. Their genetic organization is identical with that of isolates from Europe and North America, confirming a common evolutionary origin. However, the comparison of homologous proteins from these different isolates reveals a much greater extent of genetic polymorphism than previously observed. It is nevertheless possible to define conserved domains in the viral proteins, especially in the envelope, that could be of interest for the understanding of the molecular mechanisms of viral pathogenicity and for the development of diagnostic and therapeutic reagents.
PMID: 2424612 [PubMed - indexed for MEDLINE]
-
Cited by over 100 PubMed Central articles
-
Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant.
Watkins JD, Campbell GR, Halimi H, Loret EP.
Retrovirology. 2008 Sep 22; 5:83. Epub 2008 Sep 22.
[Retrovirology. 2008]
-
New and old complex recombinant HIV-1 strains among patients with primary infection in 1996-2006 in France: the French ANRS CO06 primo cohort study.
Frange P, Galimand J, Vidal N, Goujard C, Deveau C, Souala F, Peeters M, Meyer L, Rouzioux C, Chaix ML.
Retrovirology. 2008 Aug 1; 5:69. Epub 2008 Aug 1.
[Retrovirology. 2008]
-
Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1.
Costa LJ, Chen N, Lopes A, Aguiar RS, Tanuri A, Plemenitas A, Peterlin BM.
Retrovirology. 2006 Jun 9; 3:33. Epub 2006 Jun 9.
[Retrovirology. 2006]
- » See all...