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A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.
Protein-tyrosine kinases are implicated in the control of normal and neoplastic cell growth. We have used molecular cloning strategies to characterize a lymphocyte-specific protein-tyrosine kinase gene distinct from but closely related to src and yes. This gene, encoded by a genetic locus defined here as lskT, is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Thus alterations in the structure or expression of this protein-tyrosine kinase gene may in some cases mediate neoplastic transformation. In addition, transcription of the normal lskT gene is restricted to cells of lymphoid origin. We infer that the lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes.
PMID: 2416464 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A.
J Biol Chem. 2008 May 30; 283(22):15419-30. Epub 2008 Mar 31.
[J Biol Chem. 2008]
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Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.
Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A.
Mol Cell Biol. 2005 Jun; 25(12):4924-33.
[Mol Cell Biol. 2005]
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Large-scale identification of disease genes involved in acute myeloid leukemia.
Erkeland SJ, Valkhof M, Heijmans-Antonissen C, van Hoven-Beijen A, Delwel R, Hermans MH, Touw IP.
J Virol. 2004 Feb; 78(4):1971-80.
[J Virol. 2004]
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