Cloning and expression of a cDNA encoding a novel ...[FEBS Lett. 1990]

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1: FEBS Lett. 1990 Jun 18;266(1-2):187-91. Links

Cloning and expression of a cDNA encoding a novel human neurotrophic factor.

Kaisho Y, Yoshimura K, Nakahama K.

Biotechnology Research Laboratories, Takeda Chemical Industries Ltd, Osaka, Japan.

A cDNA encoding a novel human neurotrophic factor (designated nerve growth factor-2; NGF-2) was cloned from a human glioma cDNA library using a synthetic DNA corresponding to human nerve growth factor (NGF). The cloned cDNA encodes a polypeptide composed of 257 amino acid residues including a prepro-sequence of 138 residues and a mature region of 119 residues. The amino acid sequence of human NGF-2 exhibits 58% similarity with that of human NGF. Conditioned medium of COS-7 cells transfected with an expression plasmid for human NGF-2 cDNA supported the survival of sensory neurons isolated from dorsal root ganglia of embryonic chicks. A 1.5 kb of NGF-2 mRNA can be detected from an early development stage in rat brain, by Northern blotting analysis.

PMID: 2365067 [PubMed - indexed for MEDLINE]

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.
Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5454-8.

[Proc Natl Acad Sci U S A. 1990]
Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.
Mol Cell Biol. 1993 Jul; 13(7):4251-9.

[Mol Cell Biol. 1993]
Brain-derived neurotrophic factor is more highly conserved in structure and function than nerve growth factor during vertebrate evolution.
J Neurochem. 1992 Aug; 59(2):432-42.

[J Neurochem. 1992]
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
Science. 1990 Mar 23; 247(4949 Pt 1):1446-51.

[Science. 1990]
ReviewHuman nerve growth factor: biological and immunological activities, and clinical possibilities in neurodegenerative disease.
Adv Exp Med Biol. 1991; 296:207-25.

[Adv Exp Med Biol. 1991]
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Cited by 16 PubMed Central articles

Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo.
Neveu I, Arenas E. J Cell Biol. 1996 May; 133(3):631-46.

[J Cell Biol. 1996]
An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.
Ibáñez CF, Ilag LL, Murray-Rust J, Persson H. EMBO J. 1993 Jun; 12(6):2281-93.

[EMBO J. 1993]
Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.
Metsis M, Timmusk T, Arenas E, Persson H. Proc Natl Acad Sci U S A. 1993 Oct 1; 90(19):8802-6.

[Proc Natl Acad Sci U S A. 1993]
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Cited by 16 PubMed Central articles

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