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Sequence of a cDNA encoding human galactose-1-phosphate uridyl transferase.
Department of Pediatrics, Emory University, Atlanta, GA 30322.
We report a revised sequence of a cDNA that encodes a human galactose-1-phosphate uridyl transferase. The cDNA is 1295 bases in length and encodes a 43,000 Mr protein. The sequence was derived from a cDNA clone isolated from a transformed human lymphoblast cell line and amplified in a polymerase chain reaction. The revised sequence reveals a higher degree of amino acid conservation between the human enzyme and the homologous enzymes from Escherichia coli and yeast than was previously thought to exist.
PMID: 2233247 [PubMed - indexed for MEDLINE]
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Cited by 11 PubMed Central articles
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ARHI: A new target of galactose toxicity in Classic Galactosemia.
Lai K, Tang M, Yin X, Klapper H, Wierenga K, Elsas L.
Biosci Hypotheses. 2008; 1(5):263-271.
[Biosci Hypotheses. 2008]
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Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.
Slepak TI, Tang M, Slepak VZ, Lai K.
Mol Genet Metab. 2007 Sep-Oct; 92(1-2):78-87. Epub 2007 Jul 20.
[Mol Genet Metab. 2007]
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Molecular basis for Duarte and Los Angeles variant galactosemia.
Langley SD, Lai K, Dembure PP, Hjelm LN, Elsas LJ.
Am J Hum Genet. 1997 Feb; 60(2):366-72.
[Am J Hum Genet. 1997]
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