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1: J Biol Chem. 1990 Aug 5;265(22):12955-9.Click here to read Links

Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family.

Lipkin VM, Khramtsov NV, Vasilevskaya IA, Atabekova NV, Muradov KG, Gubanov VV, Li T, Johnston JP, Volpp KJ, Applebury ML.

Shemyakin Institute of Bioorganic Chemistry, Union of Soviet Socialist Republics Academy of Sciences, Moscow.

A group of cDNA clones encoding the beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase were isolated for structural analysis. The encoded polypeptide has 853 residues with a calculated molecular mass of 98 kDa. The beta-subunit is 72% identical to the rod cGMP phosphodiesterase alpha-subunit. Like the alpha-subunit and the cone alpha'-subunit, the beta-subunit belongs to the family of phosphodiesterase genes. The beta- and alpha-subunits are more similar to each other than either is to the cone alpha'-subunit, suggesting either that the beta- and alpha-subunits diverged more recently or that their divergence was restrained by the rod functional environment.

PMID: 2165490 [PubMed - indexed for MEDLINE]