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1: Virology. 1990 Jun;176(2):656-7.Links

Nucleotide sequence analyses of the genes encoding the HN, M, NP, P, and L proteins of two host range mutants of Sendai virus.

Middleton Y, Tashiro M, Thai T, Oh J, Seymour J, Pritzer E, Klenk HD, Rott R, Seto JT.

Department of Microbiology, California State University, Los Angeles 90032.

Comparative nucleotide sequence analyses of the genome of Sendai virus (strain Z) and two host range mutants, ts-f1 and F1-R, previously described revealed that the ts defect of ts-f1 can be attributed to two nucleotide exchanges in the NP gene. These exchanges lead to a single amino acid substitution. A single base pair change was found in both the P and L genes of F1-R, but not of ts-f1. Both host range mutants have the two same exchanges in the M gene. These additional mutations are discussed concerning their significance in the pantropic properties of the host range mutants.

PMID: 2161155 [PubMed - indexed for MEDLINE]