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Human placenta contains an epithelial scatter protein.
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510.
Scatter factor (SF) is a protein produced by cultured fibroblasts which causes epithelia to "scatter" into isolated cells. We found significant scatter activity in vivo in second trimester (but not term) human amniotic fluid and in human placenta. Placental SF was purified 500,000-fold and identified as a protein with Mr 78 kd. Factor scattered Madin-Darby canine kidney and human squamous carcinoma cells at 15 pM. Amino acid sequences from tryptic peptides did not match any known protein. Human placental fibroblasts produced high titers of scatter activity. SF may be involved in development and may enhance carcinoma invasion.
PMID: 2140676 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium.
Coffer A, Fellows J, Young S, Pappin D, Rahman D.
Biochem J. 1991 Aug 15; 278 ( Pt 1):35-41.
[Biochem J. 1991]
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Evidence for the identity of human scatter factor and human hepatocyte growth factor.
Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Rieder H, Fonatsch C, Tsubouchi H, Hishida T, Daikuhara Y.
Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7001-5.
[Proc Natl Acad Sci U S A. 1991]