Antithrombin III: structural and functional aspect...[Biochimie. 1990] - PubMed Result

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1: Biochimie. 1990 Aug;72(8):599-608.Links

Antithrombin III: structural and functional aspects.

Mourey L, Samama JP, Delarue M, Choay J, Lormeau JC, Petitou M, Moras D.

Laboratoire de Cristallographie Biologique, IBMC du CNRS, Strasbourg, France.

Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.

PMID: 2126464 [PubMed - indexed for MEDLINE]

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Structures reported by this article

Crystal Structure Of Cleaved Bovine Antithrombin Iii At 3.2 Angstroms Resolution

PDB: 1ATT

Source: Bos taurus

Method: X-Ray Diffraction | Resolution: 3.2 Å

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