Nucleotide sequence of the LYS2 gene of Saccharomy...[Gene. 1991]

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1: Gene. 1991 Feb 1;98(1):141-5. Links

Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1.

Morris ME, Jinks-Robertson S.

Department of Biology, Emory University, Atlanta, GA 30322.

The Saccharomyces cerevisiae LYS2 gene, which encodes alpha-aminoadipate reductase, an essential enzyme in the yeast lysine biosynthetic pathway, has been sequenced. A large open reading frame (ORF) has been identified which can specify a 1392-amino acid protein with a deduced Mr of 155,344. A DNA database search using the translated LYS2 ORF as a probe has revealed significant aa sequence homology to the Bacillus brevis enzyme tyrocidine synthetase 1.

PMID: 2013406 [PubMed - indexed for MEDLINE]

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[Curr Genet. 1998]
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[Mol Genet Metab. 2001]
ReviewGenetic regulation of asparagine-linked oligosaccharide synthesis.
Biochem Soc Trans. 1991 Aug; 19(3):642-5.

[Biochem Soc Trans. 1991]
Review[Secretion of proteins by Bacillus brevis]
Tanpakushitsu Kakusan Koso. 1992 Feb; 37(3 Suppl):258-68.

[Tanpakushitsu Kakusan Koso. 1992]
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Cited by 11 PubMed Central articles

Molecular evolution of adenylating domain of aminoadipate reductase.
An KD, Nishida H, Miura Y, Yokota A. BMC Evol Biol. 2003 May 8; 3:9. Epub 2003 May 8.

[BMC Evol Biol. 2003]
Aminoadipate reductase gene: a new fungal-specific gene for comparative evolutionary analyses.
An KD, Nishida H, Miura Y, Yokota A. BMC Evol Biol. 2002 Apr 3; 2:6. Epub 2002 Apr 3.

[BMC Evol Biol. 2002]
Novel posttranslational activation of the LYS2-encoded alpha-aminoadipate reductase for biosynthesis of lysine and site-directed mutational analysis of conserved amino acid residues in the activation domain of Candida albicans.
Guo S, Evans SA, Wilkes MB, Bhattacharjee JK. J Bacteriol. 2001 Dec; 183(24):7120-5.

[J Bacteriol. 2001]
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Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1.

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Cited by 11 PubMed Central articles

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