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Isolation of a cDNA probe for the human intestinal dipeptidylpeptidase IV and assignment of the gene locus DPP4 to chromosome 2.
Unité de Recherche sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, INSERM U178, Villejuif, France.
We report the nucleotide sequence and derived amino-acid sequence of a cDNA clone encoding the 3' end of human intestinal dipeptidylpeptidase IV (DPP-IV). This cDNA probe identifies a 4 kb mRNA in the human colon cancer cell line Caco-2. We demonstrate here an extensive homology between this human DPP-IV cDNA and the recently published rat liver DPP-IV cDNA. Using the human DPP-IV cDNA to probe genomic DNA from a panel of somatic cell hybrids we have assigned the gene encoding human DPP-IV to chromosome 2.
PMID: 1977364 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Activity of hepatocyte nuclear factor 1alpha and hepatocyte nuclear factor 1beta isoforms is differently affected by the inhibition of protein phosphatases 1/2A.
Carrière V, Lacasa M, Rousset M.
Biochem J. 2001 Mar 1; 354(Pt 2):301-8.
[Biochem J. 2001]
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GalNAc-alpha-O-benzyl inhibits NeuAcalpha2-3 glycosylation and blocks the intracellular transport of apical glycoproteins and mucus in differentiated HT-29 cells.
Huet G, Hennebicq-Reig S, de Bolos C, Ulloa F, Lesuffleur T, Barbat A, Carrière V, Kim I, Real FX, Delannoy P, et al.
J Cell Biol. 1998 Jun 15; 141(6):1311-22.
[J Cell Biol. 1998]
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Sugar-dependent expression of the fructose transporter GLUT5 in Caco-2 cells.
Mesonero J, Matosin M, Cambier D, Rodriguez-Yoldi MJ, Brot-Laroche E.
Biochem J. 1995 Dec 15; 312 ( Pt 3):757-62.
[Biochem J. 1995]
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