-
Primary structure and morphine-like activity of human beta-endorphin.
The complete amino acid sequence of human beta-endorphin was obtained by automatic sequencing of a sulfonyl isothiocyanate derivative of this peptide, in combination with peptide mapping of a tryptic digest of the native molecule. It was found to be identical with the carboxy-terminal portion 61-91 of human beta-lipotropin (beta-LPH). The morphine-like activity of beta-endorphin is comparable both in the mouse vas deferens bioassay and in the opiate receptor binding assay. However, beta-LPH is not active up to concentrations of 10(-6) M.
PMID: 195688 [PubMed - indexed for MEDLINE]
-
Cited by 3 PubMed Central articles
-
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M.
Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):928-33. Epub 2003 Jan 27.
[Proc Natl Acad Sci U S A. 2003]
-
ReviewDistribution of beta-endorphin-related peptides in rat pituitary and brain.
Zakarian S, Smyth DG.
Biochem J. 1982 Mar 15; 202(3):561-71.
[Biochem J. 1982]
-
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.
Rossier J, Vargo TM, Minick S, Ling N, Bloom FE, Guillemin R.
Proc Natl Acad Sci U S A. 1977 Nov; 74(11):5162-5.
[Proc Natl Acad Sci U S A. 1977]