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Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus.
The glyceraldehyde 3-phosphate dehydogenase holoenzyme of Bacillus stearothermophilus possesses precise 222 symmetry: in this respect it differs from the reported structure of the lobster muscle enzyme. Pairs of active sites are linked through a flexible polypeptide loop which probably mediates the structural changes giving rise to cooperative effects. Three additional salt bridges made by each subunit to others would make a major contribution to thermostability of the tetramer.
PMID: 193030 [PubMed - indexed for MEDLINE]
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Cited by 32 PubMed Central articles
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Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.
Kim H, Deng L, Xiong X, Hunter WD, Long MC, Pirrung MC.
J Med Chem. 2007 Jul 26; 50(15):3423-6. Epub 2007 Jun 27.
[J Med Chem. 2007]
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Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942.
Kitatani T, Nakamura Y, Wada K, Kinoshita T, Tamoi M, Shigeoka S, Tada T.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1; 62(Pt 8):727-30. Epub 2006 Jul 29.
[Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006]
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Structure of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942 complexed with NADP.
Kitatani T, Nakamura Y, Wada K, Kinoshita T, Tamoi M, Shigeoka S, Tada T.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1; 62(Pt 4):315-9. Epub 2006 Mar 10.
[Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006]
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Structures reported by this article